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排序方式: 共有934条查询结果,搜索用时 231 毫秒
91.
Joaquín Prada Jiménez de Cisneros Michael J. Stear Colette Mair Darran Singleton Thorsten Stefan Abigail Stear Glenn Marion Louise Matthews 《Journal of the Royal Society Interface》2014,11(99)
Gastrointestinal nematodes are a global cause of disease and death in humans, wildlife and livestock. Livestock infection has historically been controlled with anthelmintic drugs, but the development of resistance means that alternative controls are needed. The most promising alternatives are vaccination, nutritional supplementation and selective breeding, all of which act by enhancing the immune response. Currently, control planning is hampered by reliance on the faecal egg count (FEC), which suffers from low accuracy and a nonlinear and indirect relationship with infection intensity and host immune responses. We address this gap by using extensive parasitological, immunological and genetic data on the sheep–Teladorsagia circumcincta interaction to create an immunologically explicit model of infection dynamics in a sheep flock that links host genetic variation with variation in the two key immune responses to predict the observed parasitological measures. Using our model, we show that the immune responses are highly heritable and by comparing selective breeding based on low FECs versus high plasma IgA responses, we show that the immune markers are a much improved measure of host resistance. In summary, we have created a model of host–parasite infections that explicitly captures the development of the adaptive immune response and show that by integrating genetic, immunological and parasitological understanding we can identify new immune-based markers for diagnosis and control. 相似文献
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94.
Azizi O Hubler D Schrader G Farrell J Chaplin BP 《Environmental science & technology》2011,45(24):10582-10590
This research investigated the mechanism of perchlorate (ClO(4)(-)) formation from chlorate (ClO(3)(-)) on boron-doped diamond (BDD) film anodes by use of a rotating disk electrode reactor. Rates of ClO(4)(-) formation were determined as functions of the electrode potential (2.29-2.70 V/standard hydrogen electrode, SHE) and temperature (10-40 °C). At all applied potentials and a ClO(3)(-) concentration of 1 mM, ClO(4)(-) production rates were zeroth-order with respect to ClO(4)(-) concentration. Experimental and density functional theory (DFT) results indicate that ClO(3)(-) oxidation proceeds via a combination of direct electron transfer and hydroxyl radical oxidation with a measured apparent activation energy of 6.9 ± 1.8 kJ·mol(-1) at a potential of 2.60 V/SHE. DFT simulations indicate that the ClO(4)(-) formation mechanism involves direct oxidation of ClO(3)(-) at the BDD surface to form ClO(3)(?), which becomes activationless at potentials > 0.76 V/SHE. Perchloric acid is then formed via the activationless homogeneous reaction between ClO(3)(?) and OH(?) in the diffuse layer next to the BDD surface. DFT simulations also indicate that the reduction of ClO(3)(?) can occur at radical sites on the BDD surface to form ClO(3)(-) and ClO(2), which limits the overall rate of ClO(4)(-) formation. 相似文献
95.
Daniela K?nnicke Alexandra Kühn Thorsten Mahrholz Michael Sinapius 《Journal of Materials Science》2011,46(21):7046-7055
Nanoscale aluminium trihydroxide (ATH) is examined to its suitability for carbon fibre reinforced plastics (CFRP) as a novel
flame retardant. In particular the influence of particle size and concentration of ATH to the fire behaviour of epoxy polymer
matrices is determined. The particle size is adjusted by means of different dispersing techniques. By SEM images and viscosity
measurements the homogeneity of the produced ATH dispersions for the liquid ones and of cured epoxy–ATH nanocomposites is
determined. Based on these pre-results, selected ATH dispersions are used for the manufacturing of CFRP which are produced
by the proved injection technology. The thermal stability of the ATH nanocomposite plates and the corresponding CFRP plates
are analyzed by means of quantitative single difference thermoanalysis (QSDTA). The fire behaviour is characterised by using
the OSU chamber test. Both tests indicate a reduced heat release rate by decreasing the ATH particle size, i.e. the thermal
load decreases. A combined fire protection mechanism is discussed for the improved fire protection through ATH nanoparticles. 相似文献
96.
Three-dimensional laser-induced fluorescence (3DLIF) was applied to visualize and quantitatively analyze mixing in a lab-scale UV reactor consisting of one lamp sleeve placed perpendicular to flow. The recirculation zone and the von Karman vortex shedding that commonly occur in flows around bluff bodies were successfully visualized. Multiple flow paths were analyzed by injecting the dye at various heights with respect to the lamp sleeve. A major difference in these pathways was the amount of dye that traveled close to the sleeve, i.e., a zone of higher residence time and higher UV exposure. Paths away from the center height had higher velocities and hence minimal influence by the presence of sleeve. Approach length was also characterized in order to increase the probability of microbes entering the region around the UV lamp. The 3DLIF technique developed in this study is expected to provide new insight on UV dose delivery useful for the design and optimization of UV reactors. 相似文献
97.
Thorsten Kirsch Fenglin Zhang Olivia Braender-Carr Mary K. Cowman 《International journal of molecular sciences》2021,22(13)
Mesenchymal stem cells (MSCs) obtained from various sources, including bone marrow, have been proposed as a therapeutic strategy for the improvement of tissue repair/regeneration, including the repair of cartilage defects or lesions. Often the highly inflammatory environment after injury or during diseases, however, greatly diminishes the therapeutic and reparative effectiveness of MSCs. Therefore, the identification of novel factors that can protect MSCs against an inflammatory environment may enhance the effectiveness of these cells in repairing tissues, such as articular cartilage. In this study, we investigated whether a peptide (P15-1) that binds to hyaluronan (HA), a major component of the extracellular matrix of cartilage, protects bone-marrow-derived MSCs (BMSCs) in an inflammatory environment. The results showed that P15-1 reduced the mRNA levels of catabolic and inflammatory markers in interleukin-1beta (IL-1β)-treated human BMSCs. In addition, P15-1 enhanced the attachment of BMSCs to HA-coated tissue culture dishes and stimulated the chondrogenic differentiation of the multipotential murine C3H/10T1/2 MSC line in a micromass culture. In conclusion, our findings suggest that P15-1 may increase the capacity of BMSCs to repair cartilage via the protection of these cells in an inflammatory environment and the stimulation of their attachment to an HA-containing matrix and chondrogenic differentiation. 相似文献
98.
Thorsten Falk Ralf Heese Christian Kaspar Malgorzata Mochol Daniel Pfeiffer Michael Thygs Robert Tolksdorf 《Informatik-Spektrum》2006,29(3):201-209
Zusammenfassung The importance of the Internet for job procurement is increasing for the reason that three quarters of the people in the employment age are online. On the other hand because ever more companies are publishing their job offers on the Web. However, due to the large number of openings published online it is almost impossible for job seekers and job portals to gain an overview of the entire employment market. Since job offers lack semantically meaningful annotations, the search and integration into databases are made highly difficult. Applying Semantic Web technologies to the e-recruitment process provides advantages for all participants in the market. In this paper we describe a method for analysing the domain-specific language of an application domain. We use this method to describe the e-recruitment process and the necessary ontologies for annotating job offers and job applications. In conclusion, we present the prototypical implementation of the scenario based on Semantic Web, especially semantic matching. 相似文献
99.
We investigate numerically the interaction of a stream of granular particles with a resting obstacle in two dimensions. For the case of high stream velocity we find that the force acting on the obstacle is proportional to the square of the stream velocity, the density and the obstacle size. This behaviour is equivalent to that of non-interacting hard spheres. For low stream velocity a gap between the obstacle and the incoming stream particles appears which is filled with granular gas of high temperature and low density. As soon as the gap appears the force does not depend on the square of velocity of the stream but the dependency obeys another law. 相似文献
100.
Test and evaluation of a solar powered gas turbine system 总被引:3,自引:1,他引:2
Peter Heller Markus Pfnder Thorsten Denk Felix Tellez Antonio Valverde Jesús Fernandez Arik Ring 《Solar Energy》2006,80(10):1225-1230
This paper describes the test and the results of a first prototype solar powered gas turbine system, installed during 2002 in the CESA-1 tower facility at Plataforma Solar de Almería (PSA) in Spain. The main goals of the project were to develop a solar receiver cluster able to provide pressurized air of 1000 °C and solve the problems arising from the coupling of the receivers with a conventional gas turbine to demonstrate the operability of the system. The test set-up consists of the heliostat field of the CESA-1 facility providing the concentrated solar power, a pressurized solar receiver cluster of three modules of 400 kWth each which convert the solar power into heat, and a modified helicopter engine (OST3) with a generator coupled to the grid. The first test phase at PSA started in December 2002 with the goal to reach a temperature level of 800 °C at the combustor air inlet by the integration of solar energy. This objective was achieved by the end of this test phase in March 2003, and the system could be operated at 230 kWe power to grid without major problems. In the second test phase from June 2003 to August 2003 the temperature level was increased to almost 1000 °C. The paper describes the system configuration, the component efficiencies and the operation experiences of the first 100 h of solar operation of this very successful first test of a solar operated Brayton gas turbine system. 相似文献